Prior flavivirus immunity skews the yellow fever vaccine response to expand cross-reactive antibodies with increased risk of antibody dependent enhancement of Zika and dengue virus infection
A. Santos-Peral, F. Luppa, S. Goresch, E. Nikolova, M. Zaucha, L. Lehmann, F. Dahlstroem, H. Karimzadeh, B. M. Kummerer, J. Thorn-Seshold, E. Winheim, G. Dobler, M. Hoelscher, S. Endres, A. B. Krug, , S. Rothenfusser
This study shows that prior TBEV immunity alters the YF17D vaccine response, leading to cross-reactive antibodies that increase the risk of ADE for dengue and Zika.
bioRxiv · May 7, 2023 · PreprintImmunology