Author

J. Thorn-Seshold

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

C. Heise· 3 shared O. Thorn-Seshold· 3 shared A. Akhmanova· 2 shared H. Karimzadeh· 2 shared J. C. M. Meiring· 2 shared L. Gao· 2 shared S. Rothenfusser· 2 shared A. B. Krug· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

C. Heise

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Prior flavivirus immunity skews the yellow fever vaccine response to expand cross-reactive antibodies with increased risk of antibody dependent enhancement of Zika and dengue virus infection

A. Santos-Peral, F. Luppa, S. Goresch, E. Nikolova, M. Zaucha, L. Lehmann, F. Dahlstroem, H. Karimzadeh, B. M. Kummerer, J. Thorn-Seshold, E. Winheim, G. Dobler, M. Hoelscher, S. Endres, A. B. Krug, , S. Rothenfusser

This study shows that prior TBEV immunity alters the YF17D vaccine response, leading to cross-reactive antibodies that increase the risk of ADE for dengue and Zika.

bioRxiv · May 7, 2023 · PreprintImmunology

Cyclic dichalcogenides extend the reach of bioreductive prodrugs to harness the thioredoxin system: applications to seco-duocarmycins

J. G. Felber, A. Kitowski, L. Zeisel, M. S. Maier, C. Heise, J. Thorn-Seshold, O. Thorn-Seshold

This paper introduces a new class of bioreductive prodrugs activated by the thioredoxin system, showing in vivo efficacy against breast and pancreatic cancer.

bioRxiv · Nov 11, 2022Biochemistry

A high-throughput neutralization assay for yellow fever serodiagnostics

M. Rasulova, T. Vercruysse, J. Paulissen, C. Coun, V. Suin, L. Heyndrickx, J. Ma, K. Geerts, J. Timmermans, N. Mishra, L.-H. Li, D. B. Kum, L. Coelmont, S. Van Gucht, H. Karimzadeh, , H. J. Thibaut

This paper develops a high-throughput fluorescence-based assay (SNTFLUO) for detecting yellow fever neutralizing antibodies, validated against WHO standards and applicable for differential diagnostics.

bioRxiv · Dec 16, 2021 · PreprintMicrobiology

Photoswitchable epothilone-based microtubule stabilisers allow GFP imaging-compatible, optical control over the microtubule cytoskeleton

L. Gao, J. C. M. Meiring, C. Heise, A. Rai, A. Mueller-Deku, A. Akhmanova, J. Thorn-Seshold, O. Thorn-Seshold

This paper introduces photoswitchable epothilone reagents (STEpos) that allow optical control over microtubule stability and dynamics with high spatiotemporal precision.

bioRxiv · Mar 31, 2021Cell Biology

In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M

L. Gao, J. C. M. Meiring, A. Varady, I. E. Ruider, C. Heise, M. Wranik, C. D. Velasco, J. A. Taylor, B. Terni, J. Standfuss, C. C. Cabernard, A. Llobet, M. O. Steinmetz, A. R. Bausch, M. Distel, , O. Thorn-Seshold

This paper introduces two new photoswitchable reagents for in vivo control of microtubule dynamics and related processes, showing their effectiveness in 3D systems and model organisms.

bioRxiv · Mar 26, 2021Cell Biology