BioengineeringbioRxiv
Site-specific PEGylation crosslinking of L-asparaginase subunits to improve its therapeutic efficiency
J. Ramirez-Paz, M. Saxena, L. J. Delinois…·K. Griebenow
This paper improves L-asparaginase therapeutic efficiency through site-specific PEGylation of subunits, increasing molecular weight and extending half-life without compromising catalytic activity.
DOI 10.1371/journal.pone.0197643