Site-specific PEGylation crosslinking of L-asparaginase subunits to improve its therapeutic efficiency
J. Ramirez-Paz, M. Saxena, L. J. Delinois, F. M. Joaquin-Ovalle, S. Lin, Z. Chen, V. A. Rojas-Nieves, K. Griebenow
This paper improves L-asparaginase therapeutic efficiency through site-specific PEGylation of subunits, increasing molecular weight and extending half-life without compromising catalytic activity.
bioRxiv · May 8, 2018Bioengineering