Author

M. Saxena

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

A. K. Gupta· 2 shared A. K. Srivastava· 2 shared A. Mishra· 2 shared K. Varshney· 2 shared S. Jain· 2 shared A. A. Gumerova· 1 shared A. Gaikwad· 1 shared A. K. Saxena· 1 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. K. Gupta

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity

S. Gera, T.-C. Kuo, F. Korkmaz, D. Sant, V. DeMambro, A. A. Gumerova, K. Sudha, A. Padilla, G. Prevot, J. Munitz, A. Teunissen, M. M. T. van Leent, T. G. J. M. Post, J. C. Fernandes, J. Netto, , M. Zaidi

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

bioRxiv · Feb 28, 2022 · PreprintPharmacology & Toxicology

Synthesis, SAR and Docking Studies of Substituted Aryl phenylthiazolyl phenylcarboxamide as potential PTP-1B Inhibitors

K. Varshney, A. K. Gupta, A. Rawat, R. Srivastava, A. Mishra, M. Saxena, A. K. Srivastava, S. Jain, A. K. Saxena

The paper synthesizes and evaluates substituted aryl phenylthiazolyl phenylcarboxamides as PTP-1B inhibitors, identifying compound 38 as a potent inhibitor with in vivo metabolic benefits.

bioRxiv · Mar 4, 2019Pharmacology & Toxicology

Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity

K. Varshney, A. K. Gupta, R. Sonkar, S. Varshney, A. Mishra, G. Bhatia, A. Gaikwad, A. K. Srivastava, M. Saxena, S. Jain, A. Saxena

This study synthesizes and evaluates oxopropanylindole hydrazone derivatives for antioxidant and anti-dyslipidemic activity, identifying 6c as the most effective compound.

bioRxiv · Nov 25, 2018Biochemistry

Tumor suppressor DAPK1 catalyzes adhesion assembly on rigid but anoikis on soft matrices

R. Qin, H. Wolfenson, M. Saxena, M. Sheetz

This study shows DAPK1 promotes adhesion on rigid matrices and triggers anoikis on soft matrices through phosphorylation and interaction with rigidity-sensing modules.

bioRxiv · Jul 6, 2018Cell Biology

Site-specific PEGylation crosslinking of L-asparaginase subunits to improve its therapeutic efficiency

J. Ramirez-Paz, M. Saxena, L. J. Delinois, F. M. Joaquin-Ovalle, S. Lin, Z. Chen, V. A. Rojas-Nieves, K. Griebenow

This paper improves L-asparaginase therapeutic efficiency through site-specific PEGylation of subunits, increasing molecular weight and extending half-life without compromising catalytic activity.

bioRxiv · May 8, 2018Bioengineering