Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics
M. J. A. de Haan, F. M. R. Witjas, A. M. A. de Graaf, M. E. Jacobs, E. Sanchez-Lopez, S. Kostidis, M. A. Giera, M. Maanaoui, T. Hubert, J. Kerr-Conte, F. Pattou, D. K. de Vries, J. Kers, I. P. J. Alwayn, C. van Kooten, , T. J. Rabelink
This study demonstrates that sub normothermic perfusion can preserve human kidneys metabolically for up to 8 days, maintaining metabolic activity and functional parameters for at least 4 days.
bioRxiv · May 10, 2023 · PreprintBioengineering