Author

M. E. Jacobs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. M. A. de Graaf· 1 shared A. Schambach· 1 shared B. P. A. M. Heijs· 1 shared C. Harper· 1 shared C. Mason· 1 shared C. N. Barese· 1 shared C. Oborski· 1 shared C. van Kooten· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

A. M. A. de Graaf

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2 papers

Recent·Most cited

Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics

M. J. A. de Haan, F. M. R. Witjas, A. M. A. de Graaf, M. E. Jacobs, E. Sanchez-Lopez, S. Kostidis, M. A. Giera, M. Maanaoui, T. Hubert, J. Kerr-Conte, F. Pattou, D. K. de Vries, J. Kers, I. P. J. Alwayn, C. van Kooten, , T. J. Rabelink

This study demonstrates that sub normothermic perfusion can preserve human kidneys metabolically for up to 8 days, maintaining metabolic activity and functional parameters for at least 4 days.

bioRxiv · May 10, 2023 · PreprintBioengineering

Screening of Chimeric GAA Variants in a Preclinical Study of Pompe Disease Results in Candidate Vector for Hematopoietic Stem Cell Gene Therapy

Y. Dogan, C. N. Barese, J. W. Schindler, J. K. Yoon, Z. Unnisa, S. Guda, M. E. Jacobs, C. Oborski, D. L. Clarke, A. Schambach, R. Pfeifer, C. Harper, C. Mason, N. P. van Til

This study screens chimeric GAA variants in a preclinical Pompe disease model, identifying a candidate vector for hematopoietic stem cell gene therapy that reduces glycogen accumulation and CNS vacuolation.

bioRxiv · Dec 28, 2021Bioengineering