Author

F. Pattou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Kerr-Conte· 5 shared A. Bonnefond· 2 shared C. Bourouh· 2 shared C. Carney· 2 shared E. Courty· 2 shared F. Oger· 2 shared J.-S. Annicotte· 2 shared L. Rolland· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPhysiology

J. Kerr-Conte

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Author profile →

5 papers

Recent·Most cited

Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes

A. Coomans de Brachene, M. I. Alvelos, F. Szymczak, P. L. Zimath, A. Castela, B. Marmontel de Souza, A. Roca Rivada, S. Marin-Canas, X. Yi, A. Op de Beeck, N. G. Morgan, S. Sonntag, S. Jawurek, A. C. Title, B. Yesildag, , D. L. Eizirik

This study identifies IFN and IFNγ as key cytokines affecting pancreatic beta cells in type 1 diabetes through RNA-sequencing analysis and comparison with T1D islet signatures.

bioRxiv · Jun 29, 2023Immunology

Advancing multi-day ex vivo kidney perfusion using spatially resolved metabolomics

M. J. A. de Haan, F. M. R. Witjas, A. M. A. de Graaf, M. E. Jacobs, E. Sanchez-Lopez, S. Kostidis, M. A. Giera, M. Maanaoui, T. Hubert, J. Kerr-Conte, F. Pattou, D. K. de Vries, J. Kers, I. P. J. Alwayn, C. van Kooten, , T. J. Rabelink

This study demonstrates that sub normothermic perfusion can preserve human kidneys metabolically for up to 8 days, maintaining metabolic activity and functional parameters for at least 4 days.

bioRxiv · May 10, 2023 · PreprintBioengineering

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

F. Cuozzo, K. Viloria, A. H. Shilleh, D. Nasteska, C. Frazer-Morris, Z. Jiao, A. Boufersaoui, B. Marzullo, H. R. Smith, C. Bonner, J. Kerr-Conte, F. Pattou, R. Nano, L. Piemonti, P. R. Johnson, , D. J. Hodson

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

bioRxiv · Dec 21, 2022 · PreprintPhysiology

A crosstalk between E2F1 and GLP-1 signaling pathways modulates insulin secretion

C. Bourouh, E. Courty, G. Pasquetti, X. Gromada, N. Rabhi, C. Carney, M. Moreno, R. Boutry, L. Rolland, E. Caron, Z. Benfodda, P. Meffre, J. Kerr-Conte, F. Pattou, P. Froguel, , J.-S. Annicotte

This study shows that E2F1 and GLP-1 signaling pathways interact to regulate insulin secretion and glucose homeostasis in beta cells.

bioRxiv · Apr 16, 2021Physiology

Pancreatic β-cell specific loss of E2f1 impairs insulin secretion and β-cell identity through the epigenetic repression of non β-cell programs

F. Oger, C. Bourouh, X. Gromada, M. Moreno, C. Carney, E. Courty, N. Rabhi, E. Durand, S. Amanzougarene, L. Berberian, M. Derhourhi, L. Rolland, S. A. Hannou, P.-D. Denechaud, Z. Benfodda, , J.-S. ANNICOTTE

bioRxiv · Oct 14, 2020Physiology