Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome
E. Radaelli, C.-A. Assenmacher, E. Banerjee, F. Manero, S. Khiati, A. Girona, G. Lopez-Lluch, P. Navas, M. Spinazzi
This study shows that PARL deficiency in mice causes testicular atrophy and male infertility due to ferroptosis in spermatocytes, independent of neurodegeneration.
bioRxiv · Nov 22, 2022Cell Biology