Author

C.-A. Assenmacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

E. Radaelli· 3 shared D. Sorobetea· 2 shared I. E. Brodsky· 2 shared J. P. Grayczyk· 2 shared M. Lanza· 2 shared R. Matsuda· 2 shared S. T. Peterson· 2 shared A. Bartel· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

E. Radaelli

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A TNF-IL-1 circuit controls Yersinia within intestinal granulomas

R. Matsuda, D. Sorobetea, J. Zhang, S. T. Peterson, J. P. Grayczyk, B. Herrmann, W. Yost, R. O'Neill, A. C. Bohrer, M. Lanza, C.-A. Assenmacher, K. D. Mayer-Barber, S. Shin, I. E. Brodsky

This study identifies a monocyte-intrinsic TNF-IL-1 circuit that controls Yersinia infection within intestinal granulomas by signaling to non-hematopoietic cells.

bioRxiv · Apr 21, 2023 · PreprintImmunology

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

Z. Xiao, L. Tood, L. Huang, E. Noguera-Ortega, Z. Lu, L. Huang, M. Kopp, Y. Li, N. B. Pattada, W. Zhong, W. Guo, J. Schollor, M. Liousia, C.-A. Assenmacher, C. H. June, , E. Pure

This study shows that targeting FAP+CAFs in desmoplastic pancreatic tumors reduces stromal barriers, enhances T cell infiltration, and improves response to immunotherapy.

bioRxiv · Apr 13, 2023Immunology

Mitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome

E. Radaelli, C.-A. Assenmacher, E. Banerjee, F. Manero, S. Khiati, A. Girona, G. Lopez-Lluch, P. Navas, M. Spinazzi

This study shows that PARL deficiency in mice causes testicular atrophy and male infertility due to ferroptosis in spermatocytes, independent of neurodegeneration.

bioRxiv · Nov 22, 2022Cell Biology

Inflammatory monocytes promote pyogranuloma formation to counteract Yersinia blockade of host defense

D. Sorobetea, R. Matsuda, S. T. Peterson, J. P. Grayczyk, I. Rao, E. Krespan, M. Lanza, C.-A. Assenmacher, D. P. Beiting, E. Radaelli, I. E. Brodsky

This study shows that Yersinia pseudotuberculosis induces pyogranulomas in the murine intestine by blocking phagocytosis, and that monocytes are essential for granuloma formation and immune control.

bioRxiv · Feb 6, 2022 · PreprintMicrobiology

Computer-Assisted Mitotic Count Using a Deep Learning-based Algorithm Improves Inter-Observer Reproducibility and Accuracy in canine cutaneous mast cell tumors

C. A. Bertram, M. Aubreville, T. A. Donovan, A. Bartel, F. Wilm, C. Marzahl, C.-A. Assenmacher, K. Becker, M. Bennett, S. Corner, B. Cossic, D. Denk, M. Dettwiler, B. G. Gonzalez, C. Gurtner, , R. Klopfleisch

bioRxiv · Jun 4, 2021Pathology

RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signalling

K. Chen, B. Demarco, R. Heilig, S. Ramos, J. Grayczyk, C.-A. Assenmacher, E. Radaelli, L. Joannas, J. Henao-Mejia, I. Brodsky, P. Broz

The paper shows that RIPK1 activates GSDME in neutrophils to promote anti-Yersinia defence through pyroptosis and IL-1β release.

bioRxiv · Jan 20, 2021Immunology