Priming enables a NEK7-independent route of NLRP3 activation
N. A. Schmacke, M. M. Gaidt, I. Szymanska, F. O'Duill, C. A. Stafford, D. Chauhan, A. L. Froehlich, D. Nagl, F. Pinci, J. L. Schmid-Burgk, V. Hornung
This study shows that NEK7 is not required for NLRP3 activation in human and murine cells under pro-inflammatory conditions when TAK1-dependent priming is active.
bioRxiv · Oct 9, 2019 · PreprintImmunology