V. Hornung

β1 integrin signaling governs necroptosis via the chromatin remodeling factor CHD4

The paper shows that β1 integrin signaling regulates necroptosis through CHD4-mediated repression of Ripk3 in fibrosis.

Tumor necrosis factor is a necroptosis-associated alarmin

This study identifies TNF as a necroptosis-associated alarmin by showing that necroptosis promotes TNF translation and release through ADAM protease activation.

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

Nanoscale organization of the endogenous ASC speck

This study uses super-resolution microscopy to analyze the nanoscale structure of endogenous ASC specks during NLRP3 inflammasome activation, revealing a dense core with extending filaments and changes in density during formation.

Clostridium difficile Toxin B activates the NLRP3 inflammasome in human macrophages, demonstrating a novel regulatory mechanism for the Pyrin inflammasome

The paper shows that C. difficile toxin B activates the NLRP3 inflammasome in human macrophages, not the Pyrin inflammasome, and that Pyrin activation can be restored with prolonged priming.

HBV DNA is a substrate for the cGAS/STING pathway but is not sensed in infected hepatocytes

This study shows HBV DNA is sensed by cGAS/STING in hepatocytes but is not detected during infection due to capsid shielding, while HBV RNAs are not immunostimulatory.

Priming enables a NEK7-independent route of NLRP3 activation

This study shows that NEK7 is not required for NLRP3 activation in human and murine cells under pro-inflammatory conditions when TAK1-dependent priming is active.