D. Chauhan

Advancing Tolerogenic Immunotherapy: A Multi-Epitope Vaccine Design Targeting the CYP2D6 Autoantigen in Autoimmune Hepatitis Through Immuno-Informatics

This paper designs a multi-epitope tolerogenic vaccine targeting CYP2D6 for autoimmune hepatitis using immuno-informatics, showing it induces IL-10 and programs dendritic cells toward a tolerogenic state.

Intrabacterial regulation of a cytotoxic effector by its cognate metaeffector promotes Legionella pneumophila virulence

This study shows that MesI, a metaeffector of Legionella pneumophila, regulates the cytotoxic effector SidI within the bacterium, which is critical for virulence.

Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions

This study shows that the L. pneumophila effector LegC4 enhances host defense against the pathogen under inflammatory and oxidative stress by subverting the host proteasome activator PA28β.

Long Noncoding RNA RROL Provides Chromatin Scaffold for MYC-WDR82 Interaction to Impact Lipid Metabolism and Tumor Cell Growth in Multiple Myeloma

This study identifies RROL as a therapeutically actionable lncRNA in multiple myeloma that supports tumor growth through chromatin scaffolding of MYC-WDR82 interaction.

Priming enables a NEK7-independent route of NLRP3 activation

This study shows that NEK7 is not required for NLRP3 activation in human and murine cells under pro-inflammatory conditions when TAK1-dependent priming is active.