Mast Cell Derived Histamine Negatively Regulates Hematopoiesis
B. R. Klein, J. N. P. Smith, R. Katabathula, R. Chaudhary, Z. Gao, B. A. Cordova, F. Petroze, R. Tiwari, S. L. Gerson, R. Xu, S. D. Markowitz, A. B. Desai
This study shows mast cell-derived histamine suppresses hematopoietic stem cell function, as evidenced by increased hematopoiesis in histamine-deficient mice and reversal with exogenous histamine.
bioRxiv · Feb 3, 2022Immunology