Z. Gao

Tissue-like Viscoelasticity Drives Muscle Stem Cell Expansion Through Mechanical Memory Formation

This study shows that tissue-like viscoelastic substrates enhance muscle stem cell expansion by creating mechanical memory through focal adhesion stabilization and Rac-Akt signaling.

In-depth investigation of the mechanisms of high and low residual feed intake regulating hens during the late laying period via liver and gut microbiota.

Cas1 mediates the interference stage in a phage-encoded CRISPR-Cas system

This study identifies Cas1 as mediating the interference stage in a phage-encoded CRISPR-Cas system, revealing its role in connecting Cas2/3 to the DNA-bound Cascade complex.

Self-amplifying ROS-sensitive SN38 Dimeric Prodrug nanoparticles for Combined Chemotherapy and Ferroptosis in Cancer Treatment

This paper develops SN38-CA@FC NPs, a ROS-sensitive dimeric prodrug nanoparticle that combines chemotherapy and ferroptosis to treat cancer, showing potent antitumor activity in cell lines and mouse models.

Evaluation of the effects of ripening-related genes on fruit metabolites and the associated regulatory mechanisms in tomato

The paper evaluates the effects of ripening-related genes on tomato fruit metabolites and identifies regulatory mechanisms, showing that HY5 mutation increases fructose and glucose levels by modulating SWEET12c expression.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Human microbiota is a reservoir of SARS-CoV-2 advantageous mutations

The paper identifies that the human microbiota contributes to SARS-CoV-2 mutations by replicating bacterial mRNAs with advantageous mutations, leading to chimeric RNAs and altered viral properties.

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Membrane Mimetic-Dependence of GPCR Energy Landscapes

This study investigates how temperature affects the conformational landscape of the A2A adenosine receptor, showing drug efficacy and membrane mimetic dependence.

Mesenchymal-specific Alms1 knockout in mice recapitulates key metabolic features of Alström Syndrome

This study shows that deleting Alms1 in mesenchymal cells in mice causes metabolic issues similar to Alström Syndrome, including insulin resistance and fatty liver.

Dissecting MPXV neurotropism and host antiviral signaling using human stem cell-based models

This study investigates MPXV neurotropism and antiviral signaling in CNS cells using human stem cell-derived models, finding that glial cells are more susceptible and exhibit reduced type I IFN responses.

A vast repertoire of secondary metabolites influences community dynamics and biogeochemical processes in cold seeps

This study investigates secondary metabolites in cold seep microbiomes using metagenomic, metatranscriptomic, and metabolomic data, revealing diverse biosynthetic gene clusters and their potential ecological roles.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

The paper develops an automated in vitro sonodynamic therapy system for glioblastoma and demonstrates its efficacy in inducing apoptosis and reducing 3D growth of glioma cells.

Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell Lines

This study characterizes 52 patient-derived glioma cell lines with whole-genome sequencing, RNA-seq, and drug response screening, identifying three subtypes and their drug sensitivities and tumorigenic potential.

High Sensitivity Top-down Proteomics Captures Single Muscle Cell Heterogeneity in Large Proteoforms

This study develops a sensitive top-down proteomics method to analyze large proteoforms in single muscle cells, revealing heterogeneity and linking it to muscle fiber types.

MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

Attenuation of polysialic acid biosynthesis in cells by the small molecule inhibitor 8-keto-sialic acid

The paper describes 8-keto-sialic acid as a non-toxic inhibitor that blocks polysialic acid synthesis by terminating chain elongation in cancer and immune cells.

Swim bladder resonance enhances hearing in crucian carp (Carassius auratus)

The paper demonstrates that swim bladder resonance enhances hearing in crucian carp through auditory evoked potentials, Micro-CT, and numerical simulations.

Limited role of generation time changes in driving the evolution of mutation spectrum in humans

The paper examines how changes in generation time affect human mutation spectra, finding that such changes cannot fully explain observed mutation patterns, suggesting other factors are involved.

Mast Cell Derived Histamine Negatively Regulates Hematopoiesis

This study shows mast cell-derived histamine suppresses hematopoietic stem cell function, as evidenced by increased hematopoiesis in histamine-deficient mice and reversal with exogenous histamine.

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

The paper identifies a mutation in the SARS-CoV-2 Omicron variant's structural envelope protein that reduces ion channel calcium permeability and acid sensitivity, leading to lower cell damage and cytokine production.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

A well conserved archaeal B-family polymerase functions as a mismatch and lesion extender

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

Diterpenoid Vinigrol activates ATF4/DDIT3-mediated PERK/eIF2 arm of unfolded protein response to drive breast cancer cell death

This study identifies Vinigrol as a broad-spectrum anti-cancer agent that activates the PERK/eIF2 arm of the UPR via ATF4/DDIT3 to induce breast cancer cell death.

LENG8 regulation of mRNA processing, is responsible for the control of mitochondrial activity

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

AUTS2 controls neuronal lineage choice through a novel PRC1-independent complex and BMP inhibition

This study identifies a novel AUTS2-containing complex that inhibits BMP signaling to promote neuronal differentiation and reveals its role in neuronal lineage specification.