Author

A. B. Desai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pathology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

J. N. P. Smith· 7 shared S. D. Markowitz· 6 shared K. F. Christo· 5 shared S. L. Gerson· 4 shared A. Jogasuria· 2 shared A. P. Jogasuria· 2 shared A. V. Broncano· 2 shared B. A. Cordova· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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7 shared papersImmunology

J. N. P. Smith

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Author profile →

7 papers

Recent·Most cited

Sex-specific niche signaling contributes to sexual dimorphism following stem cell transplantation

J. N. P. Smith, B. A. Cordova, B. Richardson, K. F. Christo, J. Campanelli, A. V. Broncano, J. Chen, J. Lee, S. J. Cameron, J. D. Lathia, W. A. Goodman, M. J. Cameron, A. B. Desai

This paper identifies sex-specific niche signaling differences in hematopoietic regeneration following stem cell transplantation and shows exogenous sex hormones regulate hematopoietic stem and progenitor cells.

bioRxiv · Jun 13, 2022 · PreprintImmunology

Mast Cell Derived Histamine Negatively Regulates Hematopoiesis

B. R. Klein, J. N. P. Smith, R. Katabathula, R. Chaudhary, Z. Gao, B. A. Cordova, F. Petroze, R. Tiwari, S. L. Gerson, R. Xu, S. D. Markowitz, A. B. Desai

This study shows mast cell-derived histamine suppresses hematopoietic stem cell function, as evidenced by increased hematopoiesis in histamine-deficient mice and reversal with exogenous histamine.

bioRxiv · Feb 3, 2022Immunology

Polymer microparticles prolong delivery of the 15-PGDH inhibitor SW033291

A. B. Dogan, N. A. Rohner, J. N. P. Smith, J. A. Kilgore, N. S. Williams, S. D. Markowitz, H. A. von Recum, A. B. Desai

This paper develops a sustained release platform using β-CD microparticles to extend the delivery of the 15-PGDH inhibitor SW033291 beyond one week.

bioRxiv · Aug 15, 2021Bioengineering

15-PGDH Regulates Hematopoietic and Gastrointestinal Fitness During Aging

W. J. Ho, J. N. P. Smith, Y. S. Park, M. Hadiono, K. F. Christo, A. Jogasuria, Y. Zhang, A. V. Broncano, L. Kasturi, D. M. Dawson, S. L. Gerson, S. D. Markowitz, A. B. Desai

This study shows that 15-PGDH inhibition improves hematopoietic and gastrointestinal tissue fitness in aged mice by enhancing regeneration and reducing inflammation.

bioRxiv · Dec 22, 2020 · PreprintPathology

15-PGDH Inhibition Activates the Splenic Niche to Promote Hematopoietic Regeneration

J. N. P. Smith, D. M. Dawson, K. F. Christo, A. P. Jogasuria, M. J. Cameron, M. I. Antczak, J. M. Ready, S. L. Gerson, S. D. Markowitz, A. B. Desai

This study shows that inhibiting 15-PGDH enhances splenic support for hematopoietic stem and progenitor cells, improving hematopoietic regeneration after bone marrow transplantation.

bioRxiv · Sep 17, 2020Cell Biology

Inhibition of 15-PGDH Protects Mice from Immune-mediated Bone Marrow Failure

J. N. P. Smith, F. Otegbeye, A. Jogasuria, K. F. Christo, S. L. Gerson, S. D. Markowitz, A. B. Desai

This study shows that inhibiting 15-PGDH with SW033291 improves hematologic recovery and survival in a murine model of immune-mediated bone marrow failure.

bioRxiv · Apr 7, 2020Immunology

Therapeutic Targeting of 15-PGDH in Murine Idiopathic Pulmonary Fibrosis

J. N. P. Smith, M. D. Witkin, A. P. Jogasuria, K. F. Christo, T. M. Raffay, S. D. Markowitz, A. B. Desai

This study shows that inhibiting 15-PGDH with a small molecule reduces fibrosis and improves lung function in a mouse model of IPF.

bioRxiv · Dec 16, 2019Pathology