Endogenous Staphylococcus aureus CRISPR-cas system limits phage proliferation and efficiently excises from the genome as part of the SCCmec cassette
K. Mikkelsen, J. Z. Bowring, Y. K. Ng, F. S. Frisinger, J. K. Maglegaard, Q. Li, R. N. Sieber, A. Petersen, P. S. Andersen, J. T. Rostoel, N. M. Hoeyland-Kroghsbo, H. Ingmer
This study shows that S. aureus CRISPR-Cas systems, located within SCCmec cassettes, limit phage proliferation but are inefficient, with phages able to escape or overload the system.
bioRxiv · Mar 19, 2023 · PreprintMicrobiology