Author

F. Siegerist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Pathology· 2

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 3 Organism:human· 2 Assay:imaging· 2 Organism:zebrafish· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

N. Endlich· 6 shared C. Chatziantoniou· 3 shared K. Endlich· 3 shared C. Chadjichristos· 2 shared E. Hay· 2 shared J. S. Dikou· 2 shared M. Schindler· 2 shared S. Daniel· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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6 shared papersCell Biology

N. Endlich

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6 papers

Recent·Most cited

The tricellular junction protein ILDR2 in glomerulopathies: insights and implications

F. Siegerist, F. Kliewe, E. Hammer, P. Schakau, J. E. C. Soh, C. Weber, V. Puelles, M. Lindenmeyer, S. Reichelt-Wurm, V. Drenic, C. Chatziantoniou, C. Chadjichristos, Y. Zhang, M. Nauck, U. Völker, N. Endlich

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

bioRxiv · May 3, 2024 · PreprintCell Biology

A super-resolution compatible workflow for highly multiplexed immunofluorescence of routinely processed kidney tissue

F. Siegerist, S. Kitzel, N. Telli, J. S. Dikou, V. Drenic, C. E. Chadjichristos, C. Chatziantoniou, N. Endlich

This paper introduces a workflow for highly multiplexed immunofluorescence compatible with super-resolution microscopy, validated using a mouse model and human dataset.

bioRxiv · Dec 11, 2023 · PreprintCell Biology

Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish

M. Klawitter, F. Siegerist, S. Daniel, M. Schindler, N. Endlich

This study introduces Nifurpirinol as a more efficient prodrug for inducing FSGS-like glomerular injury in zebrafish larvae, suitable for high-content drug screening.

bioRxiv · Dec 7, 2023 · PreprintCell Biology

scoMorphoFISH: A Deep-Learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry

F. Siegerist, E. Hay, J. S. Dikou, A. Buescher, J. Oh, S. Ribback, U. Zimmermann, J. H. Braesen, O. Lenoir, K. Endlich, P.-L. Tharaux, N. Endlich

scoMorphoFISH provides a deep-learning tool for spatial single-cell mRNA quantification and morphometry in kidney biopsies, enabling single-mRNA resolution analysis.

Journal of Cellular and Molecular Medicine · Jun 1, 2022Peer-reviewedPathology

Super-resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

F. Tesch, F. Siegerist, E. Hay, N. Artelt, C. Daniel, K. Amann, U. Zimmermann, P. Kavvadas, O. Grisk, C. Chadjichristos, K. Endlich, C. Chatziantoniou, N. Endlich

The paper uses super-resolution microscopy to show CLDN5 up-regulation in injured podocyte foot processes and links it to filtration slit changes and proteinuria.

bioRxiv · Feb 2, 2021Cell Biology

Prolonged podocyte depletion in larval zebrafish resembles mammalian focal and segmental glomerulosclerosis

K. U. I. Hansen, F. Siegerist, S. Daniel, M. Schindler, A. Blumenthal, W. Zhou, K. Endlich, N. Endlich

This study shows that podocyte-depleted zebrafish larvae develop features resembling human focal and segmental glomerulosclerosis, including proteinuria and PEC activation, and can be used for drug screening.

bioRxiv · Jul 19, 2019Pathology