Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs
K. M. Gao, K. Chiang, F. T. Korkmaz, H. P. Janardhan, C. M. Trivedi, L. J. Quinton, S. M. Gingras, K. A. Fitzgerald, A. Marshak-Rothstein
This study shows that endothelial cells expressing a STING gain-of-function mutation drive immune cell infiltration and lung disease in mice, suggesting potential therapeutic targeting of endothelial STING.
bioRxiv · Jul 27, 2023 · PreprintImmunology