A. Marshak-Rothstein

Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells

This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.

Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs

This study shows that endothelial cells expressing a STING gain-of-function mutation drive immune cell infiltration and lung disease in mice, suggesting potential therapeutic targeting of endothelial STING.

Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation.

This study shows that IgA BCR signaling enhances B cell fitness and promotes diverse IgA responses to gut commensals by rescuing low-affinity B cells and redirecting plasma cell homing.

IgD+ Age-Associated B cells are the progenitors of the main T-independent B cell response to infection that generates protective Ab and can be induced by an inactivated vaccine in the aged

The paper identifies IgD+CD21-CD23- age-associated B cells as precursors of infection-induced B cells in aged mice, which provide protective antibody responses and can be induced by inactivated vaccines.