K. A. Fitzgerald

Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

This study quantifies motor phenotypes caused by ASOs in the CNS and identifies modifications that reduce toxicity while maintaining efficacy.

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

Activation of Autoreactive Lymphocytes in the Lung by STING Gain-of-function Mutation Radioresistant Cells

This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.

Expression of a STING Gain-of-function Mutation in Endothelial Cells Initiates Lymphocytic Infiltration of the Lungs

This study shows that endothelial cells expressing a STING gain-of-function mutation drive immune cell infiltration and lung disease in mice, suggesting potential therapeutic targeting of endothelial STING.

Epigenetic regulation of innate immune genes and enhanced interleukin-10 expression underlie chronic subclinical Plasmodium chabaudi infection

This study identifies epigenetic regulation of innate immune genes and increased IL-10 expression as mechanisms underlying chronic subclinical Plasmodium chabaudi infection in mice.

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

This study identifies new regulators of IFNγ-induced MHCII in macrophages using CRISPR screens, revealing pathways involving GSK3β and MED16 that are critical for CD4+ T cell activation.

STAT3 Serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

This study shows that STAT3 Ser727 phosphorylation is essential for TLR4-induced metabolic reprogramming and IL-1β production in inflammation.