Author

F. Vermeulen

Universitair Ziekenhuis Leuven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

A. gutierrez-Guerrero· 1 shared A. Krug· 1 shared Anabela S. RamalhoiD· 1 shared Annelotte M. VonkiD· 1 shared Cornelis Korstiaan van der EntiD· 1 shared D. Hendriks· 1 shared E. Bokobza· 1 shared E. Verhoeyen· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioengineering

A. gutierrez-Guerrero

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Author profile →

2 papers

Recent·Most cited

A functional comparison of readthrough agent ELX-02 across a wide range of nonsense CFTR variants

Marlies Destoop, Anabela S. Ramalho, Iris A. L. Silva, Annelotte M. Vonk, Sylvia W.F. Suen, Marlou C. Bierlaagh, Sylvia F. Boj, Robert G.J. Vries, Jeffrey Matthijn Beekman, Kris De Boeck, Cornelis Korstiaan van der Ent, Margarida D. Amaral, F. Vermeulen, Sacha Spelier

This study evaluates ELX-02's effectiveness in restoring CFTR function across various nonsense variants using patient-derived intestinal organoids, finding limited and variable rescue effects.

Journal of Cystic Fibrosis · Sep 1, 2026Peer-reviewedMolecular Biology

Nanoblades allow high-level genome editing in organoids

V. Tiroille, A. Krug, E. Bokobza, M. Bulcaen, M. Ensinck, M. Geurts, D. Hendriks, F. Vermeulen, F. Larbret, A. gutierrez-Guerrero, M. Louise, R. Gijsbers, P. E. Mangeot, H. Clevers, M. Carlon, , E. Verhoeyen

This paper introduces nanoblade technology for efficient, low-toxicity genome editing in organoids, achieving up to 80% gene knockout in murine and human organoids.

bioRxiv · Aug 4, 2022 · PreprintBioengineering