E. Verhoeyen

ATP citrate lyase is an essential player of the metabolic rewiring induced by PTEN loss during T-ALL development.

This study identifies ATP citrate lyase (ACLY) as a critical metabolic driver in PTEN-deficient T-ALL, showing its essential role in disease progression and therapeutic targeting potential.

Multimodal Mapping of Human Lymphopoiesis Reveals B and T/NK/ILC Lineages are Subjected to Cell-Intrinsic versus Flt3L-Dependent Regulation

This study maps human lymphopoiesis using multimodal approaches, showing B and T/NK/ILC lineages are regulated differently: cell-intrinsically versus Flt3L-dependent.

Distinct Subsets of Multi-Lymphoid Progenitors Support Ontogeny-Related Changes in Human Lymphopoiesis

This study identifies three waves of multi-lymphoid progenitors in human lymphopoiesis, showing ontogeny-related shifts in lineage bias and CD127+ ELP production.

Nanoblades allow high-level genome editing in organoids

This paper introduces nanoblade technology for efficient, low-toxicity genome editing in organoids, achieving up to 80% gene knockout in murine and human organoids.

Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity

This study shows that deleting CISH enhances NK cell activation and anti-tumor responses in both mice and human cells, suggesting CISH as a therapeutic target for improving NK cell immunotherapy.

Efficient and robust NK-Cell transduction with Baboon Envelope pseudotyped lentivector: a major tool for immunotherapy

This paper demonstrates that Baboon Envelope pseudotyped lentiviral vectors efficiently transduce NK-cells, enabling CAR expression and specific killing of cancer cell lines.

Efficient genome editing in primary cells and in vivo using viral-derived "Nanoblades" loaded with Cas9/sgRNA ribonucleoproteins