Author

Sylvia W.F. Suen

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Annelotte M. VonkiD· 2 shared Cornelis Korstiaan van der EntiD· 2 shared Jeffrey Matthijn BeekmaniD· 2 shared Sacha SpelieriD· 2 shared Anabela S. RamalhoiD· 1 shared Antoni R. BlaazeriD· 1 shared Edward DompelingiD· 1 shared Els J.M. WeersinkiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

Annelotte M. VonkORCID

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2 papers

Recent·Most cited

A functional comparison of readthrough agent ELX-02 across a wide range of nonsense CFTR variants

Marlies Destoop, Anabela S. Ramalho, Iris A. L. Silva, Annelotte M. Vonk, Sylvia W.F. Suen, Marlou C. Bierlaagh, Sylvia F. Boj, Robert G.J. Vries, Jeffrey Matthijn Beekman, Kris De Boeck, Cornelis Korstiaan van der Ent, Margarida D. Amaral, F. Vermeulen, Sacha Spelier

This study evaluates ELX-02's effectiveness in restoring CFTR function across various nonsense variants using patient-derived intestinal organoids, finding limited and variable rescue effects.

Journal of Cystic Fibrosis · Sep 1, 2026Peer-reviewedMolecular Biology

FDA-Approved Drug Screening in Patient-Derived Organoids Demonstrates Potential of Drug Repurposing for Rare Cystic Fibrosis Genotypes

Eyleen de Poel, Sacha Spelier, Marne C. Hagemeijer, Peter van Mourik, Sylvia W.F. Suen, Annelotte M. Vonk, Jesse E. Brunsveld, Georgia N. Ithakisiou, Evelien Kruisselbrink, Hugo Oppelaar, Gitte Berkers, Karin M. de Winter‐de Groot, Sabine Heida-Michel, S.R. Jans, H. van Panhuis, , Jeffrey Matthijn Beekman

The paper screens 1400 FDA-approved drugs in CF patient-derived intestinal organoids using a functional assay to identify potential repurposing for rare CF genotypes.

Journal of Cystic Fibrosis · May 1, 2023Peer-reviewedMolecular Biology