SEMA3F-deficient colorectal cancer cells promote lymphangiogenesis: fatty acid metabolism replace glycolysis for energy supply during lymphatic endothelial cells proliferation in tumor hypoxia microenvironment
This study shows SEMA3F-deficient colorectal cancer cells enhance lymphangiogenesis under hypoxia by promoting fatty acid metabolism in lymphatic endothelial cells through IL-6 and PGC-1α-PPAR pathways.
bioRxiv · Dec 9, 2019 · PreprintCell Biology