Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation
T. Das, F. Zaidi, M. Farag, K. M. Ruff, T. S. Mahendran, A. Singh, X. Gui, J. Messing, J. P. Taylor, P. R. Banerjee, R. V. Pappu, T. Mittag
The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.
bioRxiv · Feb 28, 2024Biophysics