J. P. Taylor

Tunable metastability of condensates reconciles their dual roles in amyloid fibril formation

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

The paper shows that the mitochondrial unfolded protein response (UPRmt) interacts with stress granules (SGs) to regulate cellular stress responses and mitochondrial homeostasis.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Identification of small molecule inhibitors of G3BP-driven stress granule formation

This study identifies two small molecules that inhibit G3BP-driven stress granule formation and dissolve pre-existing granules, showing broad efficacy across cell types and stressors.

Dynamic mapping of proteome trafficking within and between living cells by TransitID

TransitID maps proteome trafficking between cellular compartments and between cells with nanometer resolution, revealing new roles for stress granules and intercellular signaling.

A new Karyopherin-β2 binding PY-NLS epitope of HNRNPH2 is linked to neurodevelopmental disorders

This study identifies a new Karyopherin-β2 binding epitope in HNRNPH2 linked to neurodevelopmental disorders, explaining cytoplasmic accumulation due to nuclear import defects.

MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1

This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.

Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

Ubiquitination of G3BP1 mediates stress granule disassembly in a stress-specific manner

The paper identifies ubiquitination of G3BP1 as a mechanism required for heat shock-induced stress granule disassembly through interaction with FAF2 and p97/VCP.

Ubiquitination is essential for recovery of cellular activities followingheat shock

The paper shows that stress-induced ubiquitination is essential for recovery of cellular activities following heat stress.

High fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

This paper introduces a system for high fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate, bridging in vitro and live cell studies of membraneless organelles.

Enhanced stress tolerance through reduction of G3BP and suppression of stress granules

This study shows that MAGE-B2 enhances stress tolerance by reducing G3BP and suppressing stress granules, protecting male germline cells from heat stress.

Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA

This study shows that harmine enhances the efficacy of HIV-1 latency-reversing agents by increasing transcription factor availability and reducing HEXIM1 expression.