Gigabase-scale deletion scanning of the human genome
Jonas Koeppel, Aidan Keith, Samantha R. Sgrizzi, PeiXi Chen, Riza M. Daza, Faaiz Quaisar, Eleftheria Anastasia, Zihao Song, Jay Shendure, Sudarshan Pinglay
This paper introduces Shred-seq, a method to scan large-scale deletions in the human genome, revealing essential regions including noncoding sequences and establishing a lower bound for viability.
bioRxiv · Jun 2, 2026 · PreprintGenomics