Samantha R. Sgrizzi

This paper introduces Shred-seq, a method to scan large-scale deletions in the human genome, revealing essential regions including noncoding sequences and establishing a lower bound for viability.

This paper develops strategies to redirect lipid nanoparticle targeting away from the liver and toward specific tissues using engineered proteins and antibody conjugation.

This paper introduces a semi-permeable capsule for single-cell genome sequencing, enabling uniform coverage and minimal cross-contamination for detecting genomic variants.

This paper introduces EVOLVEpro, a few-shot learning framework using protein language models to rapidly improve protein activity with minimal experimental data.

The paper identifies widespread RNA-guided nucleases in eukaryotes and their viruses, showing they can be used for genome editing in human cells.