Author

Zihao Song

University of WashingtonORCID 0000-0002-3650-9330Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Aidan KeithiD· 1 shared Brian CoventryiD· 1 shared Cameron J. GlasscockiD· 1 shared David BakeriD· 1 shared Eleftheria AnastasiaiD· 1 shared Faaiz Quaisar· 1 shared Isaac B. HiltoniD· 1 shared Jay ShendureiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperGenomics

Aidan KeithORCID

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2 papers

Recent·Most cited

Design of synthetic activators for programmable gene expression

Wei Chen, Ruopu Jiao, Brian Coventry, Xiangli Qu, Magnus S. Bauer, Long Tran, Tabitha Tcheau, Kejia Wu, Zihao Song, Nicole Roullier, Xinting Li, Cameron J. Glasscock, Isaac B. Hilton, David Baker

This study designs synthetic activators for programmable gene expression by engineering coactivator-binding proteins and demonstrates their enhanced transcriptional activation capabilities.

bioRxiv · Oct 20, 2026 · PreprintSynthetic Biology

Gigabase-scale deletion scanning of the human genome

Jonas Koeppel, Aidan Keith, Samantha R. Sgrizzi, PeiXi Chen, Riza M. Daza, Faaiz Quaisar, Eleftheria Anastasia, Zihao Song, Jay Shendure, Sudarshan Pinglay

This paper introduces Shred-seq, a method to scan large-scale deletions in the human genome, revealing essential regions including noncoding sequences and establishing a lower bound for viability.

bioRxiv · Jun 2, 2026 · PreprintGenomics