MiniCARbids: Minimalistic human binding domains specifically tailored to CAR T applications
Magdalena Teufl, Julia Mayer, Kerstin E. Holzer, Dominik Emminger, Elise Sylvander, Hayeon Baik, Fabian Schubert, Evangelia Maniaki, Ulrika Bader, Álvaro Muñoz‐López, Joerg Mittelstaet, Markus Dobersberger, Michelle C. Buri, Leander Sützl, Benjamin Salzer, , Michael W. Traxlmayr
The paper introduces miniCARbids, small human-derived CAR binding domains that show high anti-tumor potency in CAR T cells, outperforming traditional scFvs in some cases.
bioRxiv · Sep 9, 2025 · PreprintSynthetic Biology