Charlotte U. Zajc

Engineering human protein switches for functional control of CARs and transcription factors via oral drug administration

This paper describes the engineering of a molecular switch that controls CARs and transcription factors using an orally available drug, demonstrating tight regulation in vitro and in vivo.

MiniCARbids: Minimalistic human binding domains specifically tailored to CAR T applications

The paper introduces miniCARbids, small human-derived CAR binding domains that show high anti-tumor potency in CAR T cells, outperforming traditional scFvs in some cases.

Caffeine-regulated molecular switches for functional control of CAR T cells in vivo

This paper develops caffeine-responsive switches for CAR T cells, showing they can be controlled by caffeine and effectively clear tumors in mice.