PTEN and ARID1A haploinsufficiency equip colonic epithelium for oncogenic transformation
Nefeli Skoufou-Papoutsaki, Sam Adler, Shenay Mehmed, Claire E. Tume, Cora Olpe, Edward R. Morrissey, Richard Kemp, Anne-Claire Girard, Elisa B. Moutin, Chandra Sekhar Reddy Chilamakuri, Jodi L. Miller, Cecilia Lindskog, Fabian Werle, Kate Marks, Francesca Marta Perrone, , Douglas J. Winton
The paper investigates how PTEN and ARID1A haploinsufficiency in colonic epithelium contributes to oncogenic transformation by altering clone dynamics and creating a pro-tumorigenic microenvironment.
bioRxiv · Mar 27, 2024 · PreprintCancer Biology