Author

Francesca Marta Perrone

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Matthias ZilbaueriD· 2 shared April Rose FosteriD· 1 shared Aurélie CenieriD· 1 shared Camilla Salvestrini· 1 shared D. Leanne JonesiD· 1 shared Daniel R. ZerbinoiD· 1 shared Dawei SuniD· 1 shared Emma L. RawlinsiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersGenomics

Matthias ZilbauerORCID

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2 papers

Recent·Most cited

Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

Rachel D. Edgar, Francesca Marta Perrone, April Rose Foster, Felicity Payne, Sophia Lewis, Komal Nayak, Judith Kraiczy, Aurélie Cenier, Franco Torrente, Camilla Salvestrini, Robert B. Heuschkel, Kai Oliver Hensel, Rebecca Harris, D. Leanne Jones, Daniel R. Zerbino, Matthias Zilbauer

This study shows that long-term culture of human intestinal organoids leads to DNA methylation changes, altered gene expression, and functional shifts, suggesting potential confounding effects in research.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2022Peer-reviewedGenomics

A functional genetic toolbox for human tissue-derived organoids

Dawei Sun, Lewis Evans, Francesca Marta Perrone, Vanesa Sokleva, Kyungtae Lim, Saba Rezakhani, Matthias P. Lütolf, Matthias Zilbauer, Emma L. Rawlins

This paper develops a genetic toolbox for tissue-derived human organoids, enabling efficient gene manipulation through CRISPR-based methods and flow cytometry.

eLife · Oct 6, 2021Peer-reviewedDevelopmental Biology