David S. Tourigny

High-purity stem cell-derived β-cells recapitulate key transcriptional and functional features of human islets

This study develops a scalable method to produce high-purity stem cell-derived β-cells that closely mimic human islets in function and transcriptional profile.

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma

This paper identifies DLK1 as a marker of adrenocortical stem/progenitor cells that predicts malignancy in adrenocortical carcinoma and is detectable in patient serum.

PTEN and ARID1A haploinsufficiency equip colonic epithelium for oncogenic transformation

The paper investigates how PTEN and ARID1A haploinsufficiency in colonic epithelium contributes to oncogenic transformation by altering clone dynamics and creating a pro-tumorigenic microenvironment.

Simulating single-cell metabolism using a stochastic flux-balance analysis algorithm

This paper introduces SSA-FBA, a computational framework for simulating single-cell metabolism using genome-scale models and gene expression data, demonstrating its application to Mycoplasma pneumoniae.

Energetic substrate availability regulates synchronous activity in an excitatory neural network

The paper investigates how glucose availability affects synchronous activity in excitatory neural networks and finds that glucose is essential for sustaining high-frequency bursting, while lactate and pyruvate cannot substitute.