CypA is a molecular barrier to HIV emergence from Eastern chimpanzees
Michael J. Young, Fabricio Cotera, Clare C. C. Gill, Jacob A. Lewis, Frank G. Whitby, Alaa Abdellatif, Joana L. Rocha, Michael Singer, Mike A. Nalls, Faraz Faghri, Peter H. Sudmant, Owen Pornillos, Molly OhAinle
The paper identifies CypA as a molecular barrier preventing lentivirus from Eastern chimpanzees from infecting humans, due to its restriction of replication through a unique capsid feature.
bioRxiv · Sep 9, 2026 · PreprintMicrobiology