Author

Jacob A. Lewis

University of UtahORCID 0000-0001-6430-7034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Organism:chicken / avian· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Owen PornillosiD· 2 shared Alaa Abdellatif· 1 shared Barbie K. Ganser‐PornillosiD· 1 shared Clare C. C. GilliD· 1 shared Devin E. ChristenseniD· 1 shared Fabricio Cotera· 1 shared Faraz FaghriiD· 1 shared Frank G. WhitbyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Owen PornillosORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 9, 2026

CypA is a molecular barrier to HIV emergence from Eastern chimpanzees

Michael J. Young, Fabricio Cotera, Clare C. C. Gill…·Molly OhAinle

The paper identifies CypA as a molecular barrier preventing lentivirus from Eastern chimpanzees from infecting humans, due to its restriction of replication through a unique capsid feature.

DOI 10.64898/2026.09.08.747897

chicken / avianexperimental assay

𝕏 PostBluesky

MicrobiologyScience AdvancesPeer-reviewedSep 2, 2026

Lenacapavir allosterically remodels the HIV-1 capsid

Nayara F. B. dos Santos, Jacob A. Lewis, Mason Hansen…·Owen Pornillos

This study shows lenacapavir remodels HIV-1 capsid structure by altering non-covalent interactions and material properties, leading to capsid rupture and impaired viral replication.

8 citationstop 1%

humanstructural biology

𝕏 PostBluesky