Non-monotonic regulation of gene expression, neural progenitor fate and brain growth by the chromatin remodeller CHD8
Shaun Hurley, Conor Mohan, Philipp Suetterlin, Jacob Ellegood, Fabrizio Rudari, Jason P. Lerch, Cathy Fernandes, M. Albert Basson
This study investigates the effects of CHD8 mutations on brain development in mice, finding non-linear gene expression and growth changes depending on mutation severity.
bioRxiv · Nov 12, 2018 · PreprintNeuroscience