Jacob Ellegood

This study shows that 3q29Del mice exhibit reduced cerebellar volume, motor and vocal impairments, and mitochondrial dysfunction, mirroring human 3q29Del phenotypes.

In 14 BXD mouse strains, those modelling developmental coordination disorder have relatively larger cortex and smaller cerebellar/subcortical volumes; this axis tracks motor coordination but maps to no single QTL.

This study uses MRI to show that ATRX deficiency in mice leads to brain structural changes linked to autism-like behaviors, including sex-specific microcephaly and altered hippocampal and cortical volumes.

The paper quantifies gonadal and sex chromosome dosage contributions to sex differences in brain volume across multiple regions in mice, revealing their combined effects on anatomical and cellular gene expression.

The paper investigates sex differences in anatomical covariance across humans and mice, finding stronger structural covariance in females and inverse relationships between volumetric sex biases and covariance patterns.

The paper identifies hypo- and hyperconnectivity subtypes in autism using cross-species fMRI, linking them to distinct biological mechanisms in mice and humans.

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

This study shows environmental enrichment during the perinatal period alters brain structure in mice by P7, with changes in hindbrain, dorsal striatum, and medial habenula, mediated by maternal care.

The paper identifies a brain-wide twisting asymmetry in mice, similar to human cerebral petalia, using data from 3,500 animals across six cohorts.

This study identifies hemispheric asymmetry in mouse brains, revealing species-specific patterns and differences from humans, with implications for autism research.

This study shows that KDM5B deficiency in mice leads to autism-like behaviors and increased brain size, which can be mitigated by NMDAR antagonists.

This study compares sex differences in brain anatomy between humans and mice using neuroimaging, finding partial conservation of volumetric sex differences in cortical regions.

This study examines thalamocortical structural covariance in mice, identifies six thalamic clusters, and shows their association with cortical connectivity and functional organization.

This study examines age-related changes in brain structure and cognition in mice, finding volume and network differences associated with maturation and aging.

The paper examines how genetics, sex, and early life stress influence mouse behavior and brain structure using behavioral tests and structural imaging.

This study examines chronic intranasal oxytocin's effects on neuroanatomy and behavior in three autism-related mouse models, finding limited effects and no consistent response patterns.

This study identifies subtle cardiac abnormalities in ASD mouse models, highlighting heterogeneity and potential shared mechanisms with CHD.

This study shows chronic amygdala hyperactivation in mice increases anxiety and may worsen stress-induced anxiety but does not cause depressive-like behaviors.

This study develops a Ddx3x haploinsufficient mouse model to investigate DDX3X syndrome, finding developmental and behavioral abnormalities linked to brain structural changes.

This study investigates the effects of Arid1b haploinsufficiency in mice, revealing sex-dependent neuroanatomical and behavioral phenotypes associated with neurodevelopmental disorders.

This study shows that Cul3 haploinsufficiency in mice causes social and cognitive deficits, cortical volume reduction, and cytoskeletal defects, which are rescued by RhoA inhibition.

This study characterizes the effects of varying humanized androgen receptor Q tract lengths on brain anatomy and behavior in mice, finding non-linear neuroanatomical changes and no behavioral effects.

This study shows that gamma-Protocadherins are essential for the survival of GABAergic interneurons during development, preventing excessive apoptosis and ensuring proper inhibitory network formation.

The paper maps brain connectivity in 16 autism mouse models to identify four subtypes of functional connectivity abnormalities linked to different etiologies.

This study shows that deleting Atrx in mouse forebrain neurons causes male-specific spatial memory deficits linked to miR-137 dysregulation and synaptic abnormalities.

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

This study investigates the effects of CHD8 mutations on brain development in mice, finding non-linear gene expression and growth changes depending on mutation severity.

The paper investigates structural covariance in mouse brain regions, finding that it is explained by distance, transcriptomic similarity, and connectivity, with varying contributions across brain areas.

This study examines Chd8 haploinsufficient mice, finding brain overgrowth, altered gene expression, and functional connectivity changes linked to autism-like features.