Sobetirome, a thyroid hormone receptor beta agonist, is a potential therapeutic agent for pulmonary fibrosis
Thomas Bärnthaler, shuiz Ding, Taylor Sterling Adams, Kady-Ann Rose, Reina Rangel, Johad Khoury, Melika Salimi, Sabina Anderson, Liqin Lin, Karen Y. Velasco-Alzate, Fernando Poli de Frias, Giuseppe Deluliis, Fadi Nicola, Carlos Cosme, A. Justet, , Farida Ahangari
This study shows that sobetirome, a thyroid hormone receptor beta agonist, reduces pulmonary fibrosis in mice and human tissue by restoring mitochondrial function and modulating apoptosis.
bioRxiv · Sep 3, 2026 · PreprintSystems Biology