Johad Khoury

This study shows that sobetirome, a thyroid hormone receptor beta agonist, reduces pulmonary fibrosis in mice and human tissue by restoring mitochondrial function and modulating apoptosis.

This study identifies early alveolar niche disruption and aberrant epithelial reprogramming in IPF using multi-modal analyses of patient cohorts.

This study identifies VEGF-D as a key factor in maintaining lung vascular integrity during acute lung injury using single-cell RNA sequencing and functional assays.

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Single-nucleus multiomic and ex vivo lung slice profiling of human idiopathic pulmonary fibrosis identifies Alveolar Intermediate cells bridging alveolar and Aberrant Basaloid states and reveals AP-1 chromatin injury memory.

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

This study investigates GPR87's role in pulmonary fibrosis, finding it highly expressed in IPF lungs and protective against fibrosis when knocked down in multiple models.