Liqin Lin

Sobetirome, a thyroid hormone receptor beta agonist, is a potential therapeutic agent for pulmonary fibrosis

This study shows that sobetirome, a thyroid hormone receptor beta agonist, reduces pulmonary fibrosis in mice and human tissue by restoring mitochondrial function and modulating apoptosis.

Inherent Biomechanical Properties of the Lung: In vivo-Ex vivo Comparisons in Mice

This study compares in vivo and ex vivo lung biomechanics in mice, finding that thoracic structures mainly affect dynamic dissipation and heterogeneity rather than intrinsic elastic properties.

Microstructural and Biomechanical Determinants of Biological Aging

The paper develops a multimodal model to predict biological age using vascular microstructure and biomechanical parameters in mice, achieving high predictive accuracy.

Biological Aging of the Cardiopulmonary System

This study quantifies biological cardiopulmonary aging in mice by integrating biomechanics and single-cell transcriptomics, revealing non-linear aging patterns and cell-type-specific gene expression changes.

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

The paper investigates age-related changes in proximal pulmonary artery mechanics in mouse models, finding increased stiffness and collagen reorientation linked to aging biomarkers and cellular senescence.