Transcriptomic analysis of repeat expansion-ataxias uncovers distinct non-neuronal cell type-specific signatures of disease across the human brain
Zhongbo Chen, Amy R. Hicks, Jonathan Brenton, Melissa Grant‐Peters, Regina Hertfelder Reynolds, Emil Karl Gustavsson, Clarissa Rocca, Guillermo Rocamora Perez, Raquel Garza, Sonia García-Ruiz, Natalia Dominik, Claire Anderson, Toby J Curless, Kylie Montgomery, Hannah L. Macpherson, , Mina Ryten
This study uses bulk and single nuclear RNA-sequencing to analyze transcriptomic changes in repeat expansion ataxias, revealing distinct non-neuronal cell type-specific disease signatures across the human brain.
bioRxiv · Jan 3, 2025 · PreprintNeuroscience