Claudia De Sanctis

The paper identifies microglial states associated with Parkinson's disease genetic risk and Lewy body pathology using single-cell profiling and integrates data with AMP PD.

This paper shows that macroscopic and radiological perfusion metrics do not reliably predict ultrastructural preservation in brain tissue after hyperosmotic perfusion.

This study characterizes cell-type-specific transcriptomes across APOE genotypes in Alzheimer's disease using single-nuclei RNA sequencing, revealing APOE4-associated changes in excitatory neurons and microglia.

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

This paper presents a protocol for preserving fixed whole brains using aldehyde-based cryopreservation, showing preserved cellular architecture after long-term storage.

The paper identifies integrated stress response (ISR) signatures and proteostasis defects in monocytes from GBA1- and LRRK2-linked Parkinson's disease, linking them to immune dysfunction.

This study identifies endothelial type I interferon signaling as a regulator of vascular normalization after ischemic brain injury, showing it reduces BBB disruption and promotes junctional stability.

The paper evaluates ultrastructural preservation quality in postmortem brain tissue using EM and light microscopy to identify artifacts and assess their impact on research applications.

The paper presents a long-read RNA-seq atlas of microglia isoforms, identifying novel isoforms and their associations with genetic risk loci in Alzheimer's and Parkinson's disease.

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

This study shows that loss of synaptopodin impairs mGluR5-dependent mGluR-LTD at CA3-CA1 synapses, leading to protein synthesis-independent LTD mediated by endocannabinoid signaling.

This study identifies miR-218 as critical for hippocampal network stability by regulating interneuron function during early development.

The paper shows that mGluR1 stabilizes Synaptopodin in spines to enable mGluR-LTD, preserving spines with Synaptopodin/SA while eliminating others.

This study identifies mGlu1 receptor's role in regulating neuronal autophagy and shows FEZ1 mediates this regulation by linking mGlu1 to Ulk1.