Author

Laura B. Cantwell

University of Pennsylvania

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genetics· 3 Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:statistical model· 7 Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 3 Assay:whole-genome sequencing· 3 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Research Focus:database / resource· 1

Frequent Co-Authors

Amanda B. KuzmaiD· 6 shared Otto ValladaresiD· 6 shared Adam Christian NajiD· 5 shared Eden R. MartiniD· 5 shared Gerard D. SchellenbergiD· 5 shared Li‐San WangiD· 5 shared Wan‐Ping LeeiD· 5 shared William S. BushiD· 5 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Amanda B. KuzmaORCID

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Alzheimer's Disease Sequencing Project Release 4 Whole Genome Sequencing Dataset

Yuk Yee Leung, Wan‐Ping Lee, Amanda B. Kuzma, Heather Issen Nicaretta, Otto Valladares, Prabhakaran Gangadharan, Liming Qu, Yi Zhao, Youli Ren, Po‐Liang Cheng, Pavel P. Kuksa, Hui Wang, Heather White, Živadin Katanić, Lauren Bass, , Li‐San Wang

The paper provides a whole-genome sequencing dataset of 36,361 ADSP participants, including variant annotations, phenotypes, and a linkage disequilibrium panel for Alzheimer's Disease research.

Alzheimer s & Dementia · May 1, 2025Peer-reviewedGenetic & Genomic Medicine

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

Kurt W. Farrell, Jack Humphrey, Timothy S. Chang, Yi Zhao, Yuk Yee Leung, Pavel P. Kuksa, Vishakha Patil, Wan‐Ping Lee, Amanda B Kuzma, Otto Valladares, Laura B. Cantwell, Hui Wang, Ashvin Ravi, Claudia De Sanctis, Natalia Han, , Adam Naj

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

Nature Communications · Sep 9, 2024Peer-reviewedNeuroscience

Extended genome-wide association study employing the African Genome Resources Panel identifies novel susceptibility loci for Alzheimers Disease in individuals of African ancestry

Nicholas R. Ray, Brian W. Kunkle, Kara L. Hamilton‐Nelson, Jiji Thulaseedhara Kurup, Farid Rajabli, Mehmet İlyas Coşacak, Çağhan Kızıl, Melissa N. Jean‐Francois, Michael L. Cuccaro, Dolly Reyes‐Dumeyer, Laura B. Cantwell, Amanda B. Kuzma, Jeffery M. Vance, Sujuan Gao, Hugh C. Hendrie, , Christiane Reitz

Alzheimer s & Dementia · Dec 1, 2023Peer-reviewedGenetic & Genomic Medicine

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK, GRB14, and KIAA0825 as novel risk loci for Alzheimer disease: the Alzheimer Disease Genetics Consortium

Farid Rajabli, Penelope H. Benchek, Giuseppe Tosto, Nicholas A. Kushch, Jin Sha, Katrina Bazemore, Congcong Zhu, Wan‐Ping Lee, Jacob Haut, Kara L. Hamilton‐Nelson, Nicholas R. Wheeler, Yi Zhao, John J. Farrell, Michelle A. Grunin, Yuk Yee Leung, , Matthew P. Frosch

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.

medRxiv · Jul 6, 2023 · PreprintGenetic & Genomic Medicine

Data Descriptor: Human whole exome genotype data for Alzheimer's Disease

Yuk Yee Leung, Adam Christian Naj, Yi‐Fan Chou, Otto Valladares, Nicholas R. Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Kaylyn Clark, Laura B. Cantwell, Heather Issen Nicaretta, the Alzheimer’s Disease Sequencing Project, Sudha S. Seshadri, Zoran Brkanac, Carlos Cruchaga, , Li‐San Wang

This paper presents a strategy to jointly analyze 20,504 whole-exome sequencing samples from nine studies, generating high-quality variant calls and addressing batch effects from different capture kits.

bioRxiv · Oct 11, 2022 · PreprintGenetics

Manifestations of genetic risk for Alzheimer's Disease in the blood: a cross-sectional multi-omic analysis in healthy adults aged 18-90+

Laura M. Heath, John C. Earls, Andrew T. Magis, Sergey A. Kornilov, Jennifer C. Lovejoy, Cory C. Funk, Noa Rappaport, Benjamin A. Logsdon, Lara M. Mangravite, Brian W. Kunkle, Eden R. Martin, Adam Christian Naj, Nilüfer Ertekin‐Taner, Todd Eliot Golde, Leroy Hood, , Jeffrey Alan Kaye

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

Scientific Reports · Apr 12, 2022Peer-reviewedGenetics

VCPA: genomic variant calling pipeline and data management tool for Alzheimer’s Disease Sequencing Project

Yuk Yee Leung, Otto Valladares, Yi‐Fan Chou, Han‐Jen Lin, Amanda B Kuzma, Laura B. Cantwell, Liming Qu, Prabhakaran Gangadharan, Alzheimer's Disease Sequencing Project, William J. Salerno, Gerard D. Schellenberg, Li‐San Wang

VCPA is a genomic variant calling pipeline and data management tool for Alzheimer’s Disease Sequencing Project, providing variant calling and job tracking for WGS/WES data on Amazon cloud.

Bioinformatics · Oct 22, 2018Peer-reviewedBioinformatics

Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing

B K Kunkle, Benjamin Grenier‐Boley, Rebecca Sims, Joshua C. Bis, Adam Christian Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie‐Wolf, Céline Bellenguez, Aura Frizzati, Vincent Antoine Chouraki, Eden R. Martin, Kristel Sleegers, Nandini Badarinarayan, , Clive Holmes

This study performs a large GWAS of Alzheimer's disease, identifies four new risk loci, and highlights pathways involving immunity, lipid metabolism, and APP/Aβ processing.

bioRxiv · Apr 5, 2018 · PreprintGenetics