A titin missense variant drives atrial electrical remodeling and is associated with atrial fibrillation
Mahmud Arif Pavel, Hanna Chen, Michael Hill, Arvind Sridhar, Miles Barney, Jaime DeSantiago, Abhinaya Baskaran, Asia Owais, Shashank Sandu, Faisal A Darbar, Aylin Ornelas-Loredo, Bahaa Al-Azzam, Brandon Chalazan, Jalees Rehman, Dawood Darbar
The paper identifies a titin missense variant linked to atrial fibrillation through altered ion channel function and calcium homeostasis in human iPSC-derived atrial cardiomyocytes.
eLife · Jan 22, 2026Peer-reviewedGenetic & Genomic Medicine