Mahmud Arif Pavel

The paper identifies a titin missense variant linked to atrial fibrillation through altered ion channel function and calcium homeostasis in human iPSC-derived atrial cardiomyocytes.

This study shows GABA induces GABAAR translocation to PIP2 clusters in neurons, with astrocytic cholesterol influencing this process and affecting receptor function.

The paper shows mechanical force activates TREK-1 channels via PLD2 and lipid clustering, leading to second messenger signaling and ion flow.

This study identifies lipid rafts and phospholipase D2 (PLD2) as targets of inhaled anesthetics, showing they disrupt rafts to activate TREK-1 channels and induce loss of consciousness.

This paper identifies five deleterious nsSNPs in the human p53 gene using multiple computational tools and validates their potential to contribute to oncogenesis.