The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS
Xiaohong Sang, Haizhan Jiao, Qian Meng, Fang Xiong, Kartik S. Sundaram, Jiao Zhou, Yan Xu, Asuka Alvarado, Ruslan L. Nuryyev, Jitka Ourenik, Václav Ourednik, Iris S. Huang, Xiang Liu, Yuheng Mei, Tingli Qian, , Ziwei Huang
The paper demonstrates a synthetic dual-moiety strategy to design CXCR4 agonist peptides that mimic SDF-1, showing therapeutic benefit in a mouse model of ALS through neuroprotection.
bioRxiv · Jul 8, 2025 · PreprintNeuroscience