Author

Haizhan Jiao

Chinese University of Hong KongORCID 0000-0002-5249-2276Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

Hongli HuiD· 3 shared Aaron J. CiechanoveriD· 1 shared Asuka Alvarado· 1 shared Bin PangiD· 1 shared Bing Gan· 1 shared Donald P. PizzoiD· 1 shared Evan Y. Snyder· 1 shared Fang Xiong· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

Hongli HuORCID

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3 papers

Recent·Most cited

Mechanism of fatty acid uptake and inhibition in human FATP2

Zhenglai Zhang, Mengqing Zhou, Y Huang, Wencheng Wu, Haizhan Jiao, Minxian Dai, Taizhen Liang, Jiayue Wen, Ziqi Cheng, Xiancai Ma, Jiao Yuan, Hongli Hu, Jinsai Shang, Ronen Marmorstein, Xuepeng Wei

This paper presents cryo-EM structures of human FATP2, revealing its fatty acid uptake mechanism and drug inhibition strategies.

bioRxiv · Jul 10, 2026 · PreprintBiophysics

A Multi-Disciplinary Framework for Decoding S1PR1-Selective Agonism

Leiye Yu, Haizhan Jiao, Bin Pang, Rujuan Ti, Bing Gan, Zhaoyang Qin, Jinxin Wang, Lizhe Zhu, Hongli Hu, Ruobing Ren

The paper reports cryo-EM structures of S1PR1-Gi complexes bound to agonists and identifies molecular features driving selectivity for S1PR1 over S1PR3 and S1PR5.

bioRxiv · Aug 27, 2025 · PreprintBiochemistry

The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS

Xiaohong Sang, Haizhan Jiao, Qian Meng, Fang Xiong, Kartik S. Sundaram, Jiao Zhou, Yan Xu, Asuka Alvarado, Ruslan L. Nuryyev, Jitka Ourenik, Václav Ourednik, Iris S. Huang, Xiang Liu, Yuheng Mei, Tingli Qian, , Ziwei Huang

The paper demonstrates a synthetic dual-moiety strategy to design CXCR4 agonist peptides that mimic SDF-1, showing therapeutic benefit in a mouse model of ALS through neuroprotection.

bioRxiv · Jul 8, 2025 · PreprintNeuroscience