A histone H4K20 methylation-mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing
Muhammad Shoaib, David Walter, Peter J. Gillespie, Fanny Izard, Birthe Fahrenkrog, David Llères, Mads Lerdrup, Jens Vilstrup Johansen, Klaus H. Hansen, Eric Julien, J. Julian Blow, Claus Storgaard Sørensen
The paper identifies a chromatin compaction threshold mediated by histone H4K20 methylation that limits DNA replication licensing in G1 phase to maintain genome integrity.
Nature Communications · Sep 6, 2018Peer-reviewedMolecular Biology